Alain Eschalier Selected Research

Cold Hypersensitivity

1/2018	Targeting the TREK-1 potassium channel via riluzole to eliminate the neuropathic and depressive-like effects of oxaliplatin.
4/2014	Assessment of thermal sensitivity in rats using the thermal place preference test: description and application in the study of oxaliplatin-induced acute thermal hypersensitivity and inflammatory pain models.
1/2013	A polyamine-deficient diet prevents oxaliplatin-induced acute cold and mechanical hypersensitivity in rats.
5/2011	Oxaliplatin-induced cold hypersensitivity is due to remodelling of ion channel expression in nociceptors.
10/2008	Comparative antiallodynic activity of morphine, pregabalin and lidocaine in a rat model of neuropathic pain produced by one oxaliplatin injection.

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Alain Eschalier Research Topics

Disease

67	Pain (Aches) 09/2022 - 10/2000
36	Neuralgia (Stump Neuralgia) 10/2021 - 10/2000
29	Hyperalgesia 10/2021 - 10/2000
22	Hypersensitivity (Allergy) 12/2021 - 10/2003
11	Chronic Pain 09/2022 - 07/2006
11	Peripheral Nervous System Diseases (PNS Diseases) 12/2021 - 07/2003
11	Inflammation (Inflammations) 01/2021 - 01/2002
7	Colorectal Neoplasms (Colorectal Cancer) 12/2021 - 05/2007
7	Neoplasms (Cancer) 12/2021 - 12/2002
6	Painful Neuropathy 02/2011 - 07/2002
5	Cold Hypersensitivity 01/2018 - 10/2008
3	Breast Neoplasms (Breast Cancer) 01/2021 - 01/2019
3	Opioid-Related Disorders (Opiate Addiction) 12/2020 - 12/2016
3	Cancer Pain 01/2020 - 01/2016
3	Acute Pain 01/2013 - 07/2003
2	Constipation 10/2020 - 01/2013
2	Respiratory Insufficiency (Respiratory Failure) 10/2020 - 01/2013
2	Nociceptive Pain 01/2020 - 08/2003
2	Arthritis (Polyarthritis) 01/2017 - 05/2015
2	Schizophrenia (Dementia Praecox) 10/2016 - 08/2016
2	Postoperative Pain 04/2011 - 05/2002
2	Diabetic Neuropathies (Diabetic Neuropathy) 08/2010 - 10/2006
2	Parkinson Disease (Parkinson's Disease) 12/2005 - 02/2005
1	Migraine Disorders (Migraine) 09/2022

Drug/Important Bio-Agent (IBA)

32	Analgesics (Analgesic Drugs)IBA 01/2021 - 03/2002
16	Oxaliplatin (Eloxatin)FDA LinkGeneric 12/2021 - 04/2007
15	Acetaminophen (Paracetamol)FDA LinkGeneric 09/2022 - 05/2002
14	Opioid Analgesics (Opioids)IBA 01/2021 - 10/2000
11	Morphine (MS Contin)FDA LinkGeneric 12/2020 - 10/2000
11	Pharmaceutical PreparationsIBA 01/2018 - 05/2002
10	Antidepressive Agents (Antidepressants)IBA 10/2017 - 08/2003
8	Serotonin (5 Hydroxytryptamine)IBA 11/2018 - 07/2003
7	N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA 12/2014 - 01/2002
6	Peptides (Polypeptides)IBA 01/2021 - 08/2007
6	CarrageenanIBA 01/2021 - 07/2008
6	Proteins (Proteins, Gene)FDA Link 01/2019 - 08/2006
5	T-Type Calcium Channels (T-Type Calcium Channel)IBA 12/2019 - 07/2011
5	potassium channel protein TREK-1IBA 01/2018 - 05/2009
4	Ion Channels (Ion Channel)IBA 12/2021 - 05/2011
4	Anticonvulsants (Antiepileptic Drugs)IBA 12/2019 - 07/2003
4	Tricyclic Antidepressive Agents (Tricyclic Antidepressants)IBA 11/2018 - 06/2003
4	Streptozocin (Streptozotocin)FDA Link 01/2017 - 10/2006
4	N-Methylaspartate (NMDA)IBA 12/2013 - 03/2002
4	Dizocilpine Maleate (Dizocilpine)IBA 02/2011 - 01/2002
4	Formaldehyde (Formol)FDA Link 07/2008 - 03/2002
4	Vincristine (Oncovin)FDA LinkGeneric 07/2008 - 08/2003
3	Potassium Channels (Potassium Channel)IBA 12/2021 - 02/2016
3	Phosphotransferases (Kinase)IBA 10/2021 - 10/2006
3	Freund's AdjuvantIBA 01/2021 - 01/2011
3	Estrogen ReceptorsIBA 01/2021 - 01/2019
3	Capsaicin (Zostrix)FDA Link 01/2020 - 10/2003
3	Norepinephrine (Noradrenaline)FDA LinkGeneric 11/2018 - 06/2007
3	Duloxetine Hydrochloride (Cymbalta)FDA Link 10/2017 - 08/2012
3	Fluoxetine (Prozac)FDA LinkGeneric 10/2017 - 01/2013
3	Acid Sensing Ion ChannelsIBA 01/2017 - 04/2011
3	5-HT2A Serotonin Receptor (5 HT2A Receptor)IBA 01/2017 - 08/2010
3	Selective Serotonin Reuptake Inhibitors (Serotonin Reuptake Inhibitors)IBA 01/2017 - 08/2010
3	LigandsIBA 08/2016 - 07/2004
3	Glutamic Acid (Glutamate)FDA Link 11/2013 - 02/2005
3	Tropisetron (Navoban)IBA 06/2012 - 05/2002
3	Neuroprotective AgentsIBA 10/2009 - 07/2003
3	Venlafaxine Hydrochloride (Effexor)FDA LinkGeneric 04/2005 - 06/2003
2	serotonin 6 receptorIBA 10/2021 - 10/2020
2	Messenger RNA (mRNA)IBA 07/2021 - 01/2011
2	N-(4-hydroxyphenyl)arachidonylamide (AM404)IBA 03/2021 - 09/2008
2	4-aminophenolIBA 03/2021 - 01/2013
2	Pregabalin (Lyrica)FDA Link 01/2021 - 10/2008
2	Furylfuramide (AF2)IBA 01/2021 - 01/2019
2	GTP-Binding Proteins (G-Protein)IBA 01/2021 - 01/2019
2	Methadone (Dolophine)FDA LinkGeneric 12/2020 - 01/2018
2	Nerve Growth Factor (NGF)IBA 01/2020 - 10/2003
2	Ethosuximide (Zarontin)FDA LinkGeneric 12/2019 - 12/2016
2	Riluzole FDA LinkGeneric 01/2019 - 01/2018
2	Calcium Channels (Calcium Channel)IBA 01/2019 - 04/2014
2	Serotonin and Noradrenaline Reuptake InhibitorsIBA 10/2017 - 06/2007
2	Antipsychotic Agents (Antipsychotics)IBA 10/2016 - 08/2016
2	Cholinergic Agents (Cholinergics)IBA 12/2015 - 05/2004
2	PolyaminesIBA 04/2015 - 01/2013
2	Memantine (Namenda)FDA Link 12/2014 - 12/2013
2	Ketamine FDA LinkGeneric 12/2014 - 01/2002
2	Metabotropic Glutamate Receptors (Metabotropic Glutamate Receptor)IBA 11/2013 - 07/2008
2	Opioid Receptors (Opioid Receptor)IBA 08/2013 - 07/2004
2	Butyrates (Butyrate)IBA 07/2011 - 06/2005
2	Protein Kinases (Protein Kinase)IBA 02/2011 - 10/2006
2	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 02/2011 - 10/2006
2	U 0126 (UO 126)IBA 02/2011 - 10/2006
2	Apomorphine FDA Link 09/2006 - 12/2005
2	Cisplatin (Platino)FDA LinkGeneric 08/2006 - 07/2003
2	Ibuprofen (Motrin)FDA LinkGeneric 04/2006 - 06/2004
2	Aspirin (Acetylsalicylic Acid)FDA LinkGeneric 11/2005 - 06/2004
2	Sulfonic AcidsIBA 06/2004 - 10/2003
2	MagnesiumIBA 03/2002 - 01/2002

Therapy/Procedure

8	Drug Therapy (Chemotherapy) 12/2019 - 10/2009
8	Analgesia 01/2013 - 10/2000
7	Therapeutics 01/2021 - 10/2006
4	Ligation 10/2021 - 01/2017
2	Opiate Substitution Treatment 12/2020 - 01/2018
2	Spinal Injections 03/2016 - 07/2008
2	Enema (Enemas) 06/2005 - 06/2004
2	Pain Management 08/2003 - 12/2002